Professor Mark GumbletonPeopleCardiff University
The particle has landed characterizing the fate of inhaled pharmaceuticals. Journal of Aerosol Medicine and Pulmonary Drug Delivery 23(S2) pp. S71-S87. (10.1089/jamp.2010.0836) 2009. Campbell L.et al. 2009. Activated Extracellular Signal-Regulated Kinase Is an Independent Prognostic Factor in Clinically Confined Renal Cell Carcinoma.
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Introductionstacks.cdc.gov
In this article we provide an overview of a mechanistic model based on the multi-path particle dosimetry (MPPD) structure (ARA Inc. 2015).MPPD is a freely available dosimetry model for inhaled poorlysoluble particles and fibers which has been developed through a number of research collaborations including with the U.S. EPA and NIOSH.
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Rapid nongenomic actions of inhaled corticosteroids on
Patton JS Brain JD Davies LA Fiegel J Gumbleton M Kim KJ et al. The particle has landed--characterizing the fate of inhaled pharmaceuticals. J Aerosol Med Pulm Drug Deliv. 2010 23
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A new method for measuring lung deposition efficiency of
The Particle has Landed-Characterizing the Fate of Inhaled Pharmaceuticals. Journal of Aerosol Medicine and Pulmonary Drug Delivery 23 S71–S87 doi 10.1089/jamp.2010.0836 (2010).
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The Particle has Landed—Characterizing the Fate of Inhaled
The Particle has Landed—Characterizing the Fate of Inhaled Pharmaceuticals. December 2010. Journal of Aerosol Medicine and Pulmonary Drug Delivery 23 Suppl 2 (S2) S71-87. DOI 10.1089/jamp.2010
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Exposure to SVOCs from Inhaled Particles Impact of
Inhaled semivolatile organic compounds (SVOCs) are simultaneously present in gas and particle phases. Particles desorb a fraction of their SVOCs moving through the human respiratory tract (RT). Quantifying such desorption is challenging but important since gas- and particle-phase SVOCs deposit in different locations in the RT encountering different cell populations with varying health
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Standardized Dissolution Techniques
question to address is the fate of inhaled particles after deposition in the target region of the lung. Orally inhaled particles undergo impaction sedimentation or diffusion depending on their aerodynamic particle size. It has been shown that particles with a size ranging from 0.5 to 4 µm undergo sedimentation in the alveolar regions which is
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A new method for measuring lung deposition efficiency of
The Particle has Landed-Characterizing the Fate of Inhaled Pharmaceuticals. Journal of Aerosol Medicine and Pulmonary Drug Delivery 23 S71–S87 doi 10.1089/jamp.2010.0836 (2010).
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Thomas G O Riordan MD
require clinical studies.11 These factors determine the fate of a particle after it is inhaled. Once an aerosolized drug particle of a given size has been inhaled at a given flow the site of deposition is influenced by the anatomy of the upper and lower airways and by the patient s breathing pattern including breath-holding and the presence
Get PriceChallenges in inhaled product development and
Dec 06 2010 · The particle has landed--characterizing the fate of inhaled pharmaceuticals. Patton JS Brain JD Davies LA Fiegel J Gumbleton M Kim KJ Sakagami M Vanbever R Ehrhardt C. J Aerosol Med Pulm Drug Deliv 23 Suppl 2 S71-87 01 Dec
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Standardized Dissolution Techniques
question to address is the fate of inhaled particles after deposition in the target region of the lung. Orally inhaled particles undergo impaction sedimentation or diffusion depending on their aerodynamic particle size. It has been shown that particles with a size ranging from 0.5 to 4 µm undergo sedimentation in the alveolar regions which is
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The topical study of inhaled drug (salbutamol) delivery in
Feb 06 2018 · Patton JS et al. The particle has landed--characterizing the fate of inhaled pharmaceuticals. J Aerosol Med Pulm Drug Deliv. 201023(Suppl 2) S71–87. CAS PubMed Google Scholar 28. Cottin V Maher T. Long-term clinical and real-world experience with pirfenidone in the treatment of idiopathic pulmonary fibrosis.
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Rapid nongenomic actions of inhaled corticosteroids on
Patton JS Brain JD Davies LA Fiegel J Gumbleton M Kim KJ et al. The particle has landed--characterizing the fate of inhaled pharmaceuticals. J Aerosol Med Pulm Drug Deliv. 2010 23
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PublicationsFiegel Lab
Interaction of dipalmitoyl phosphatidylcholine monolayers with a particle-laden subphase. The particle has landedCharacterizing the fate of inhaled pharmaceuticals. J. Aerosol Med. Pulm. Drug Deliv K. Elbert A. Hawi M. Thomas J. VerBerkmoes W.A. Germishuizen P.B. Fourie A.J. Hickey D. Edwards. Inhaled large porous particles of
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Drug delivery to the lungs challenges and opportunities
Jul 21 2017 · The particle has landedcharacterizing the fate of inhaled pharmaceuticals. J. Aerosol Med. Pulm. Drug Deliv. 23(Suppl. 2) S71–S87 (2010). •• Review of issues related to the fate of deposited particles.Crossref Medline CAS Google Scholar 24
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Kinetic modeling of the retention and fate of inhaled
This paper compares the pulmonary kinetics of inhaled nano-CeO2 from published repeated inhalation studies of 1- 4- 13- and 52-week duration using a previously published kinetic model to simulate the pulmonary kinetics of inhaled micron-sized poorly soluble low toxicity particles (PSPs) in rats. This comparative analysis demonstrates that the kinetic hallmarks
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Pulmonary drug delivery from generating aerosols to
Although substantial progress has been made in this respect no signifi cant advances have been made that would lead pulmonary drug delivery beyond the treatment of some respiratory diseases. One main reason for this stagnation is the still very scarce knowledge about the fate of inhaled drug or carrier particles after deposition in the lungs.
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CHARACTERIZING UPTAKE DISTRIBUTION AND FATE OF
CHARACTERIZING UPTAKE DISTRIBUTION AND FATE OF CdSe/ZnS QUANTUM DOTS IN which are a result of particle sizes in the 1‐100 nm size scale. There are various examples of Inhaled nanoparticles attack the respiratory tract and can translocate to other organs.
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Drug delivery to the lungs challenges and opportunities
Jul 21 2017 · The particle has landedcharacterizing the fate of inhaled pharmaceuticals. J. Aerosol Med. Pulm. Drug Deliv. 23(Suppl. 2) S71–S87 (2010). •• Review of issues related to the fate of deposited particles.Crossref Medline CAS Google Scholar 24
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AIM Labsites.google
24. Patton JS Brain JD Davies LA Fiegel J Gumbleton M Kim KJ Sakagami M Vanbever R and Ehrhardt C. The particle has landed-Characterizing the fate of inhaled pharmaceuticals. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 201023 S71-S87. 25. Phalen RF Oldham MJ and Wolff RK. The relevance of animal models for aerosol studies.
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PublicationsFiegel Lab
Interaction of dipalmitoyl phosphatidylcholine monolayers with a particle-laden subphase. The particle has landedCharacterizing the fate of inhaled pharmaceuticals. J. Aerosol Med. Pulm. Drug Deliv K. Elbert A. Hawi M. Thomas J. VerBerkmoes W.A. Germishuizen P.B. Fourie A.J. Hickey D. Edwards. Inhaled large porous particles of
Get PriceProfessor Mark GumbletonPeopleCardiff University
The particle has landed characterizing the fate of inhaled pharmaceuticals. Journal of Aerosol Medicine and Pulmonary Drug Delivery 23(S2) pp. S71-S87. (10.1089/jamp.2010.0836) 2009. Campbell L.et al. 2009. Activated Extracellular Signal-Regulated Kinase Is an Independent Prognostic Factor in Clinically Confined Renal Cell Carcinoma.
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Mechanisms of absorption and elimination of drugs
Aug 07 2013 · The particle has landedcharacterizing the fate of inhaled pharmaceuticals. J. Aerosol Med. Pulm. Drug Deliv. 23(Suppl. 2) S71–S87 ( 2010 ). Seminal paper that for the first time reviews in detail the anatomy of the lung as it applies to the dynamic barriers for
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Carsten Ehrhardt Trinity ResearchTrinity College Dublin
JS Patton JD Brain LA Davies J Fiegel M Gumbleton KJ Kim M Sakagami R Vanbever C Ehrhardt The particle has landedcharacterizing the fate of inhaled pharmaceuticals J Aerosol Med Pulm Drug Deliv 23 (S2) 2010 pS71-S87 Review Article 2010 DOI TARAFull Text
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Jennifer Fiegel Ph.D.
The particle has landedCharacterizing the fate of inhaled pharmaceuticals. J. Aerosol Med. Pulm. Drug Deliv. Submitted. 2. J. A.J. Hickey D. Edwards. Inhaled large porous particles of . Curriculum VitaeJennifer Fiegel 3 Brenza M. Apicella J. Fiegel. Fate and Toxicity of Engineered Nanoparticles in a Physiologically-Relevant
Get PriceMechanisms of absorption and elimination of drugs
Aug 07 2013 · The particle has landedcharacterizing the fate of inhaled pharmaceuticals. J. Aerosol Med. Pulm. Drug Deliv. 23(Suppl. 2) S71–S87 ( 2010 ). Seminal paper that for the first time reviews in detail the anatomy of the lung as it applies to the dynamic barriers for
Get Price
Standardized Dissolution Techniques
question to address is the fate of inhaled particles after deposition in the target region of the lung. Orally inhaled particles undergo impaction sedimentation or diffusion depending on their aerodynamic particle size. It has been shown that particles with a size ranging from 0.5 to 4 µm undergo sedimentation in the alveolar regions which is
Get PricePulmonary drug delivery from generating aerosols to
The particle has landed— characterizing the fate of inhaled pharmaceuticals. J Aersosol Med Pulm D. 2010 23 S71-S87 View in Article
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The particle has landedcharacterizing the fate of
The Particle has Landed Characterizing the Fate of Inhaled Pharmaceuticals.pdf (Published (publisher s copy)Peer Reviewed) 338.7Kb Abstract Although there is a modest body of literature on the absorption of inhaled pharmaceuticals by normal lungs and some limited information from diseased lungs there is still a surprising lack of
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